MethodsThe Beta blockers in Heart Failure Collaborative Group

Our aim was to inform clinicians on the appropriate use of these important therapeutic agents for patients with HFrEF in sinus rhythm.MethodsThe Beta blockers in Heart Failure Collaborative Group (BB meta HF) is a multinational effort, combining individual data from the major randomised controlled trials investigating the use of blockers in heart failure. The group consists of the leading investigators of these trials and international experts, with the support of the four pharmaceutical companies that conducted the original trials (AstraZeneca, GlaxoSmithKline, Merck Serono, and Menarini). We included randomised controlled trials that reported mortality as a primary outcome or part of a composite outcome comparing blockers versus placebo.

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