While these complications are all possible with lamotrigine, the percentage of patients who develop them is much lower. So I think it is kind of a quantum leap in our ability to treat patients with bipolar depression and even patients with treatment resistant unipolar depression.TCR: So when you diagnose somebody with bipolar disorder, are you typically moving toward lamotrigine as a first line agent?Dr. Goldberg: Lamotrigine is frequently my initial drug of choice pandora jewellery, but as lamotrigine (to use Calabrese’s terminology) does a much better job of stabilizing from below than from stabilizing from above, frequently my patients end up on a combination of lamotrigine and lithium.TCR: Is that a combination that you find yourself using more than any other combination for bipolar disorder?TCR: Tell me a little bit then how you like to start a patient on lamotrigine, including what you tell them about it before you prescribe it, because I think the issue of Stevens Johnson Syndrome scares some patients off.Dr.
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